The long-term goals of the International Sheep Genomics Consortium (ISGC) are to develop underpinning resources for the sheep research community. This has resulted in ongoing improvement of the sheep genome assembly, its annotation and development of low, medium and high-density Illumina SNP chips. The ISGC members have made available whole genome sequence data to the community that has been captured via the Sheep Genomes Database, an initiative of the ISGC that extends the consortium's recent achievements. SheepGenomesDB is an electronic warehouse containing sequence variants called from the expanding collection of sheep genomes. Through the application of a single harmonized pipeline for read QC, mapping, variant detection and annotation, SheepGenomesDB makes available variant collections derived in a standardized manner. Run 2 has seen ~1000 animals analysed with variant collections positioned on the OAR V3.1. The consortium is now in the process of Run 3 that will include an additional ~900 animals utilizing Rambouillet v1 genome assembly with the aim of providing users with tools to obtain variants defined by chromosomal location, SNP annotation results or via animals and breeds of interest.
The historical development of resources is shown below